Nucleus Modality Relative staining intensity Mitral cell layer olfactory bulb Olfactory ++ Granular cell layer olfactory bulb Olfactory +++ External piriform layer olfactory bulb Olfactory ++ Anterior olfactory nucleus (ventral and medial) Olfactory ++ Ventral and lateral orbital cortices Limbic ++ Cingulate Limbic ++++ Motor 1 Motor ++ Motor 2 Motor ++ Dorsal endopiriform nucleus Sensory motor gating (SMG) ++++ Striatum Motor, SMG + Lateral septum Limbic, SMG ++++ Medial septum Limbic ++ Horizontal limb diagonal band of Broca Limbic ++ Subiculum Limbic + Paraventricular hypothalamic nucleus Limbic, Autonomic +++ Basal lateral amygdaloid nucleus Limbic + Anterior and posterior hypothalamus Autonomic ++ Ventrolateral geniculate nucleus, parvocellular Vision +++ Nucleus of the solitary tract Chemosensation ++++ Periaqueductal gray Analgesia ++ Median raphe nucleus Analgesia ++ Magnocellular reticular formation/ Gigantocellular reticular formation Mixed ++++ Red nucleus Motor ++++ Entorhinal cortex (medial/lateral ) Spatial memory, SMG ++++ Mammillary bodies Memory ++++ Mesencephalic nucleus of 5 Proprioception, Motor ++ Pontine gray Relay ++ Lateral vestibular nucleus Proprioception, Motor +++ Fastigial nucleus cerebellum Proprioception, Motor ++++ Posterior interposed nucleus Proprioception, Motor ++++ Inferior olivary nucleus Proprioception, Motor +++

Table 1: List of nuclei positive for the IL-2 transgene throughout the rostral-caudal extent of the brain and brainstem. (+) symbol designates relative intensity of GFP staining as visualized by fluorescence immunohistochemistry.

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