| Protein |
Control |
Alzheimer |
P- Value |
| Trophic Factors |
|
|
|
| b-NGF |
41.76 ± 4.26 |
48.60 ± 8.14 |
|
| PDGF-AA |
111.52 ± 9.94 |
59.73 ± 4.69 |
0.0002 |
| HGF |
1305.97 ± 299.12 |
3887.81 ± 691.31 |
0.0001 |
| VEGF |
195.74 ± 12.52 |
120.72 ± 9.74 |
0.0003 |
| b-FGF |
948.78 ± 81.77 |
546.07 ± 46.79 |
0.0005 |
| Cytokines |
|
|
|
| IL-1b |
123.40 ± 44.97 |
34.23 ± 7.75 |
0.028 |
| IL-6 |
316.64 ± 108.93 |
126.60 ± 91.79 |
0.009 |
| IL-8 |
806.30 ± 321.41 |
929.34 ± 185.10 |
|
| IL-10 |
18.20 ± 1.19 |
13.95 ± 0.97 |
0.008 |
| Il-16 |
2769.95 ± 244.39 |
3058.46 ± 219.60 |
|
| IL-18 |
365.60 ± 48.50 |
672.60 ± 218.45 |
|
| TNF-a |
12.95 ± 1.03 |
15.93 ± 2.72 |
|
| TRAIL |
61.14 ± 13.65 |
25.67 ± 2.84 |
0.01 |
| LIF-1 |
58.19 ± 3.02 |
51.27 ± 3.06 |
|
| SCF |
30.14 ± 3.14 |
28.14 ± 1.29 |
|
| MCP-1 (CCL2) |
1793.48 ± 559.87 |
1123.61 ± 496.75 |
0.001 |
| SDF (CXCL12) |
79.25 ± 11.76 |
29.75 ± 2.76 |
<0.0001 |
| GM-CSF |
39.05 ± 1.29 |
33.54 ± 2.83 |
|
| MIP-1 |
2279.33 ± 791.99 |
1177.78 ± 142.71 |
|
| IFN-g |
6.66 ± 0.37 |
6.93 ± 0.55 |
|
| IP-10 |
734.19 ± 479.61 |
398.13 ± 96.21 |
|
Postmortem ventricular fluid samples from aged controls or patients with
documented late-stage AD (N=10/group) were used to measure immunoreactivity
to trophic factors by direct binding ELISAs, and cytokines by multiplex bead-based
ELISAs. Immunoreactivity was normalized to protein concentration and data are
expressed as mean ± SEM of fluorescence light units (arbitrary). Inter-group
comparisons were made with the Student T-test.Significant P values are listed in
the right column. |
