Protein Control Alzheimer P- Value
Trophic Factors      
b-NGF 41.76  ±  4.26 48.60 ± 8.14  
PDGF-AA 111.52  ±  9.94 59.73 ± 4.69 0.0002
HGF 1305.97 ± 299.12 3887.81 ± 691.31 0.0001
VEGF 195.74 ± 12.52 120.72 ± 9.74 0.0003
b-FGF 948.78 ± 81.77 546.07 ± 46.79 0.0005
Cytokines      
IL-1b 123.40 ± 44.97 34.23 ± 7.75 0.028
IL-6 316.64 ± 108.93 126.60 ± 91.79 0.009
IL-8 806.30 ± 321.41 929.34 ± 185.10  
IL-10 18.20 ± 1.19 13.95 ± 0.97 0.008
Il-16 2769.95 ± 244.39 3058.46 ± 219.60  
IL-18 365.60 ±  48.50 672.60 ± 218.45  
TNF-a 12.95 ± 1.03 15.93 ± 2.72  
TRAIL 61.14 ± 13.65 25.67 ± 2.84 0.01
LIF-1 58.19 ± 3.02 51.27 ± 3.06  
SCF 30.14 ± 3.14 28.14 ± 1.29  
MCP-1 (CCL2) 1793.48 ± 559.87 1123.61 ± 496.75 0.001
SDF (CXCL12) 79.25 ± 11.76 29.75 ± 2.76 <0.0001
GM-CSF 39.05 ± 1.29 33.54 ± 2.83  
MIP-1 2279.33 ± 791.99 1177.78 ± 142.71  
IFN-g 6.66 ± 0.37 6.93 ± 0.55  
IP-10 734.19 ± 479.61 398.13 ± 96.21  
Postmortem ventricular fluid samples from aged controls or patients with documented late-stage AD (N=10/group) were used to measure immunoreactivity to trophic factors by direct binding ELISAs, and cytokines by multiplex bead-based ELISAs. Immunoreactivity was normalized to protein concentration and data are expressed as mean ± SEM of fluorescence light units (arbitrary). Inter-group comparisons were made with the Student T-test.Significant P values are listed in the right column.
Table 2: Trophic Factor and Cytokine Levels in Post-mortem Ventricular Fluid.
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