Protein |
Control |
Alzheimer |
P- Value |
Trophic Factors |
|
|
|
b-NGF |
5.69 ± 0.77 |
4.68 ± 0.17 |
P=0.10 |
PDGF |
19.88 ±1.27 |
19.19 ± 0.36 |
|
HGF |
98.00 ± 7.09 |
111.5 ± 10.44 |
|
VEGF |
89.00 ± 2.15 |
103.9 ± 2.45 |
P<0.0001 |
b-FGF |
89.81 ± 2.50 |
81.81 ± 2.29 |
P=0.025 |
Cytokines |
|
|
|
IL-1b |
6.25 ± 0.62 |
4.69 ± 0.17 |
P=0.018 |
IL-6 |
21.00 ± 3.05 |
31.19 ± 4.42 |
P=0.067 |
IL-8 |
68.25 ± 8.50 |
77.00 ± 7.70 |
|
IL-10 |
10.81 ± 0.51 |
11.50 ± 0.43 |
|
Il-16 |
14.75 ± 0.71 |
17.44 ± 0.59 |
P=0.0035 |
IL-18 |
11.81 ± 1.98 |
8.94 ± 0.83 |
P=0.095 |
TNF-a |
7.31 ± 0.66 |
6.38 ± 0.26 |
0.098 |
TRAIL |
14.94 ± 1.05 |
14.13 ± 0.39 |
|
LIF |
36.56 ± 1.82 |
41.56 ± 1.34 |
P=0.017 |
SCF |
57.63 ± 6.13 |
64.0 ± 5.08 |
|
MCP-1 (CCL2) |
2971 ± 80.11 |
3165 ± 118.3 |
P=0.093 |
SDF (CXCL12) |
21.88 ± 2.11 |
22.06 ± 1.51 |
|
GM-CSF |
28.38 ± 1.27 |
29.00 ± 0.71 |
|
MIP-1β |
85.94 ± 10.94 |
98.13 ± 6.90 |
|
IFN-g |
3.75 ± 0.62 |
3.00 ± 0.05 |
|
IP-10 |
1578 ± 155.9 |
1739 ± 121.0 |
|
CSF samples from controls (N=12) or patients with clinically diagnosed probable AD
(N=16; confirmed by postmortem exam) were used to measure immunoreactivity
to trophic factors by direct binding ELISAs, and cytokines by multiplex bead-based
ELISAs. Immunoreactivity was normalized to protein concentration and data are
expressed as mean ± SEM of fluorescence light units (arbitrary). Inter-group
comparisons were made with the Student T-test. Significant P values are listed in
the right column. |