Protein Control Alzheimer P- Value
Trophic Factors      
b-NGF 5.69 ± 0.77 4.68 ± 0.17 P=0.10
PDGF 19.88 ±1.27 19.19 ± 0.36  
HGF 98.00 ± 7.09 111.5 ± 10.44  
VEGF 89.00 ± 2.15 103.9 ± 2.45 P<0.0001
b-FGF 89.81 ± 2.50 81.81 ± 2.29 P=0.025
Cytokines      
IL-1b 6.25 ± 0.62 4.69 ± 0.17 P=0.018
IL-6 21.00 ± 3.05 31.19 ± 4.42 P=0.067
IL-8 68.25 ± 8.50 77.00 ± 7.70  
IL-10 10.81 ± 0.51 11.50 ± 0.43  
Il-16 14.75 ± 0.71 17.44 ± 0.59 P=0.0035
IL-18 11.81 ± 1.98 8.94 ± 0.83 P=0.095
TNF-a 7.31 ± 0.66 6.38 ± 0.26 0.098
TRAIL 14.94 ± 1.05 14.13 ± 0.39  
LIF 36.56 ± 1.82 41.56 ± 1.34 P=0.017
SCF 57.63 ± 6.13 64.0 ± 5.08  
MCP-1 (CCL2) 2971 ± 80.11 3165 ± 118.3 P=0.093
SDF (CXCL12) 21.88  ± 2.11 22.06 ± 1.51  
GM-CSF 28.38 ± 1.27 29.00 ± 0.71  
MIP-1β 85.94 ± 10.94 98.13 ± 6.90  
IFN-g 3.75 ± 0.62 3.00 ± 0.05  
IP-10 1578 ± 155.9 1739 ± 121.0  
CSF samples from controls (N=12) or patients with clinically diagnosed probable AD (N=16; confirmed by postmortem exam) were used to measure immunoreactivity to trophic factors by direct binding ELISAs, and cytokines by multiplex bead-based ELISAs. Immunoreactivity was normalized to protein concentration and data are expressed as mean ± SEM of fluorescence light units (arbitrary). Inter-group comparisons were made with the Student T-test. Significant P values are listed in the right column.
Table 3: CSF Trophic Factor and Cytokine Levels in Probable AD.
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