Figure 1: Schematic of chromosome 21 and trisomic gene content in mouse models of DS. The number of HSA21 or orthologous mouse classical protein coding genes (excluding keratin-associated protein genes) trisomic in each model are indicated below the chromosome. The Tc1 contains an HSA21; grey circles indicate deletions (69). The Ts65Dn is trisomic for a telomeric fragment of MMU16 plus 50 non-HSA21 orthologous protein coding genes mapping to a centromeric fragment of MMU17, indicated by the grey rectangle (67).Location of eight HSA21-encoded proteins within each model are indicated.
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