Controls Individual AD patients data range   Mean ± CV * Cut Off ( ± 2 SD) Mean ± CV * Biol Range (± 2 SD) Interlab. Var. ± 25% Aßpg/ml 790 ± 30% > 310 400 ± 33% 140 - 660 105 - 825 Taupg/ml 230 ± 60% < 510 650 ± 54% 50 -1350 40 - 1780 * Average of the ref. [1-3,5]ω

Table 6: Conceptual proposal of cut-off values (pg/mL) from mean values of normal controls (average of several reports [1-3,5] with biological variation). The range of possible data from individual Alzheimer’s patients are calculated from average of several reports [1-3,5] with biological variation and additional analytical imprecision. The cut off values are calculated for the reference range as mean ± 2 SD, i.e., including 96% of controls. The mean and SD from Alzheimer patients are also an average from the data reported [1-3,15]. The biological range in which values of AD patients are observed is based on the ± 2 SD limits including 96% of the patients. For comparison this range is extended by the additional imprecision of the inter-laboratory variations.

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