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Figure 2: The amyloid hypothesis according to the amyloid percolation well model. Aβ is a nanofoam-stabilizing agent, which stabilizes N2 bubbles in the ISF (=amyloid fibrills?), O2 bubbles within mitochondria (=mitochondrial dysfunction?) and air bubbles in the ISF (=senile plaques and CAA?). It traps NO which triggers a calcium-dependent guanylyl cyclase-mediated (GC) inflammation (=cytotoxicity by Aβ ?). Amyloid fibril from [1].
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