HIGH a3/a2 < LOW a3/a2 Cluster size (mm2) REGION SIDE STEREOTAXIC COORDINATE P THICKNESS (mm2)       x y z   HIGH LOW 61 Superior Temporal L -47 -36 9 <0.0001 2.25 ± 0.15 2.00 ± 0.18 60 Supramarginal L -40 -36 18 0.0008 1.95 ± 0.18 2.08 ± 0.19 35 Precuneus L -14 -48 58 0.0002 1.87 ± 0.14 1.98 ± 0.19 58 Superior temporal R 61 -22 -1 <0.0001 2.18 ± 0.17 2.24 ± 0.24 59 Supramarginal R 49 -29 27 <0.0001 1.94 ± 0.18 2.08 ± 0.20 52 Precuneus R 11 -49 30 0.0001 1.81 ± 0.17 1.93 ± 0.15 85 Inferior parietal R 46 -75 10 0.0001 1.94 ± 0.22 2.07 ± 0.23 61 Insula R 38 -2 3 0.0002 2.37 ± 0.28 2.57 ± 0.36 59 Postcentral L -57 -18 18 0.0002 1.51 ± 0.15 1.62 ± 0.17 71 Supramarginal L -53 -42 46 0.001 1.95 ± 0.18 2.11 ± 023 33 Precuneus L -16 -43 60 0.001 1.87 ± 0.14 1.94 ± 0.17

Table 2: Brain regions with significant regional cortical thickness differences in MCI with high a3/a2 ratio (> 1,17) compared to MCI with low a3/a2 ratio (<1,17). Cluster size represents the extension of contiguous significant voxels in the cluster obtained at p < 0.01 uncorrected (cluster size > 30 mm2). Stereotaxic coordinates reveal theposition of the most significant voxel of the cluster, and side denotes its localization on the left (L) or right (R) brain hemisphere. Thickness denotes the average cortical thickness and standard deviation values within the cluster in high and middle a3/a2 groups. P denotes the significance level of the differences in thickness between groups

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