PD + A
(n = 22)
PD – A
(n = 39)
HC
(n=19)
Statistic (ANOVA or t-test)
  Mean (SD) or n (%) F; p
Demographic variables
Age
(years)
69.32
(6.32)
66.16
(4.92)
65.79
(5.55)
F = 2.87;
p= .06
Gender
(% male)
17
(77.3)
29
(74.4)
9
(47.4)
x2  = 5.36;
p=.07
Level of formal education
(years)
12.45
(2.30)
13.00
(2.26)
13.31
(2.33)
F = 0.76;
p =.47
Disease variables
Levodopa equivalent daily dose 812.92 (522.16) 854.84 (621.21)   t= -0.27;
p = .79
Duration of PD motor symptoms (months) 123.27 (82.49) 89.24
(64.90)
  t = 1.65;
p=0.11
Age of onset of motor symptoms (years) 59.73
(10.41)
58.43
(8.34)
  t = 0.53;
p = .60
UPDRS* motor (Part III) 37.68
(12.30)
25.73
(10.00)
  t = 4.07;
P = .000
UPDRS* complications
(Part IV)
3.95
(3.58)
3.27
(3.39)
  t= 0.74;
p = .47
Hoehn-Yahr stage 2.68
(0.73)
2.20
(0.79)
  t = 2.32;
p = .02
Behavioural variables
Apathy Evaluation Scale-Clinician version 47.27
(12.13)
23.86
(7.69)
22.95 (5.06) F = 58.74;
p< .001
(post hoc:
p< .001 for both PD+A  vs PD-A and Pd-A vs HC)
Depression of any kind**, (%,DSM IV criteria) 8
(37.3)
28
(62.7)
  x2  =0.32;
p=.24
*Unified Parkinson’s Disease Rating Scale
**Including major and minor depression, dysthymia; excludes adjustment disorder or pathological grief reaction, and mood disorder due to substance abuse
Table 1: Demographic and clinical variables in three groups: Parkinson’s disease participants with and without apathy; healthy controls.
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