Figure 1: Tau phosphorylation physiological and pathological; Johnson and Stoolthoff [4]. Open Access Internet “When the phosphorylation state of tau is appropriately coordinated, it regulates neurite outgrowth and microtubule stability and dynamics. In pathological conditions in which there is an imbalance in the phosphorylation/dephosphorylation of tau, hyperphosphorylated tau can cause tau filament formation, disrupt microtubule-based processes due to decreased microtubule binding and even increase cell death.”
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