Figure 1: The deficiencies of cholinergic activities cause anti cholinergic activities (AA) by way of inflammatory processes. Because Alzheimer’s disease (AD) is well known as a disease with degeneration of cholinergic neuronal activity in the brain, the deficiencies of cholinergic neuronal activities cause the reduction of activity in anti-inflammatory process, which is called “the cholinergic anti-inflammatory pathway”, and then the up-regulation of inflammatory process. Moreover, AA is thought to appear by way of inflammations process. Therefore, in AD AA appears endogenously. We refer this “endogenous anti cholinergic cascade in Alzheimer’s disease”. Of course the more AD pathology is progressed, the more the deficiency of cholinergic neuronal is accelerated. Therefore, these relations are considered cyclic relationships.
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