Figure 2: When the level of Acetylcholine (Ach) is down-regulated substantial level in Alzheimer’s disease (AD), inflammatory process is up-regulated through down-regulated of anti inflammatory pathway. Then anticholinergic activity (AA) appears through up-regulation of inflammatory process and AA accelerates amyloidgenic pathologies. The increased amyloidgenic pathologies deteriorate Ach system more and more and the level of AA increased more and more. The amyloidgenic pathologies increase more and more. The severity of AD is faster and faster.
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