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| Figure 3: Nitric oxide synthase produces NO from L-arginine and different co-factors (NADPH, FMN, FAD and BH4). NO activates three different pathways. A) Activation of Soluble Guanylate Cyclase (sGC); B) Protein tyrosine phosphorylation and C) Modulation of protein function by S-nitrosylation. This figure represents calcium dependent isoforms (nNOS and eNOS); in the case of calcium independent isoform (iNOS) the calmodulin is not present. |
