Type Synonym Defect Serum abnormality Clinical features Serum apperance Type - I Familial hyperchylomicrnemia Low LDL, Altered Apo C- II Chylomicron Pancreatitis, Lipemia, retinalis,Skin eruptions, xanthoma, hepatosplenomegaly Creamy top layer Type - IIa Familial hypercholesterolemia LDL receptor LDL Xanthelasma, Arcus senillis , Tendon xanthomas Clear Type- IIb Familial combined hypercholesterolemia LDL receptor & Apo B LDL & VLDL   Clear Type - III Familial dysbetalipoproteinemia Apo E2 synthesis defect IDL Tubo-eruptive xanthomas, palmar xanthoma Turbid Type – IV Familial hyperprebetalipoproteinemia VLDL production, Elimination VLDL     Type – V Endogenous hypertriglyceridemia VLDL production, LPL VLDL & Chylomicron   Creamy top layer & turbid bottom. *LDL (low-density lipoprotein) **VLDL (very low-density lipoprotein) ***IDL (intermediate-density lipoprotein)

Table 1: Fredrickson classification of Hyperlipidemias.

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