Protein expression by Western-blot in different areas of the brain: hippocampus, cerebellum, cortex and limbic shown that HIF and P-53 protein are incremented in APP/PS1 transgenic mice compared with wild type. 20 μg of protein were used in each experiment and data are means ± SD for 6 independent experiments. White bar as wild type and Gris bar as APP/PS1. Tubuline is used such as control amount of protein *p<0.04 vs wild type mice.
