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| Figure 1: Alzheimer Disease pathology is influenced by genetics, epigenetics, along with environmental influence on these complex networks. Environmental influence includes, but is not limited to, oxidative stress, inflammation, and chemical exposure. In addition lifestyle factors such as diet and nutrition, tramautic brain injury, lack exercise, and smoking may have an effect. This can impact AD pathology through malfunction in regulation of genes, non coding RNAs, and changes to an individuals epigenome. |
