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| Figure 6: (a) 3D Pharmacophore model of four compounds showing geometrical relationship among pharmacophore features. Aromatic ring groups (AR) are represented by two pairs of brown meshed spheres, hydrophobic group (HD) by a cyan sphere, hydrogen bond donor (HBD) by a pair of magenta spheres, and hydrogen bond acceptor (HBA) by a pair of green spheres. The smaller sphere represents the location of the HBA atom on the ligand, while the larger one indicates the location of HBD atom on the receptor. (b) Distances (Aº) among the centers of selected features are labeled. (c-f) are the mapping patterns of 2-(thiophen-2-yl) quinazoline, N-[(E)-phenylmethylidene]-1H-imidazole- 1-carboxamide, 2-{[(1E)-(2-hydroxyphenyl)methylidene]amino}benzoic acid and 2-(1H-pyrazol-5-yl)-1H-benzimidazole to the pharmacophore, respectively. |
