Figure 2: The primary desvenlafaxine metabolites and reaction products detected in vitro using cryopreserved human hepatocytes and liver microsomes from rat, dog, and human. Rat liver microsomes produced 8 hydroxyl desvenlafaxine metabolites (6 cyclohexane ring hydroxyl metabolites, 1 ethyl group hydroxyl metabolite, and 1 benzyl group hydroxyl metabolite). Dog liver microsomes produced all hydroxyl metabolites except the ethyl group hydroxyl metabolite. Human liver microsomes produced 3 cyclohexane ring hydroxyl metabolites and the benzyl group hydroxyl metabolite. All species generated N,O-didesmethylvenlafaxine (NODV), desvenlafaxine O-glucuronide, and the reaction product desvenlafaxine N-oxide.
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