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| Figure 4: (A) Ratio of least squares geometric mean desipramine AUC values for studies comparing desipramine plus desvenlafaxine vs desipramine alone. From Preskorn et al. J Psychiatr Pract [29]. Plasma concentrations (ie, AUC and peak plasma concentration) of desipramine, a substrate probe for cytochrome P450 2D6 activity, and 2-hydroxydesipramine, the metabolite of desipramine hydroxylation by CYP2D6, were compared in subjects administered desipramine alone and in subjects administered desipramine in combination with desvenlafaxine using a 1-factor analysis of variance. (B) Mean (SD) AUC profiles of (R+S)-enantiomers of desvenlafaxine after a single oral dose of desvenlafaxine 400 mg/d with and without ketoconazole 200 mg twice daily in healthy subjects. Abbreviations: AUC, area under the plasma-concentration-vs-time curve; bid, twice daily. From Nichols et al. [26]. |
