Time (Hours) 0.1 N HCl pH 4.5 AB pH 6.8 PB Water
  R T R T R T R T
1 17 19 39 22 39 20 39 20
2 38 30 56 32 67 31 57 30
3 55 46 70 41 69 39 71 38
4 75 54 78 48 79 46 81 46
6 90 70 92 58 90 57 93 56
8 98 79 98 66 95 66 96 65
12 100 90 100 78 99 78 97 76
16 - 95 - 86 - 86 - 84
20 - 98 - 92 - 92 - 89
R-Reference formulation, T- Test formulation
Table 1: In vitro dissolution profile of Preductal® MR tablet 35 mg (Reference) and Extended Release tablet 70 mg (Test).
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