Journal of Stem Cell Research & Therapy

Amal Mahmoud El-Shazly

Publications

• Research Article
  Does Exosomes Derived Bone Marrow Mesenchymal Stem Cells Restore Ovarian Function by Promoting Stem Cell Survival on Experimentally Induced Polycystic Ovary in Adult Female Albino Rats? (Histological and Immunohistochemical Study)
  Author(s): Eman Mohammed Faruk, Rania Ebrahim El desoky, Amal Mahmoud El-Shazly and Neama Mahmoud TahaEman Mohammed Faruk, Rania Ebrahim El desoky, Amal Mahmoud El-Shazly and Neama Mahmoud Taha
  
  Poly Cystic Ovarian Syndrome (PCOS) is increasingly reported nowadays. Recently exosomes released by Mesenchymal Stem Cells (MSCs-EX) has been a novel source with a great potential donor cell in regenerative medicine because of their low immunogenicity and easy accessibility. Foeniculum vulgare (FVE) is a naturally occurring estrogen compound, which is commonly used today due to the impact of the female hormones. In this study, we evaluated the therapeutic effect of exosome released by MSCs in experimentally induced Poly Cystic Ovary (PCO). The polycystic disease was artificially induced by injecting rats daily with testosterone propionate (dissolved in propylene glycol) 1 mg/100 g body weight for 35 days. Exosomes were prepared for 3rd passage of MSCs-EX and were injected into the induced PCO rats. Another group of PCOS rats received FVE (alcoholic extra.. View More»
  DOI: 10.4172/2157-7633.1000442

  Abstract PDF