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Claudio Luparello
Claudio Luparello
Dipartimento di Scienze e Tecnologie Biologiche, Chimiche e Farmaceutiche (STEBICEF), Università di Palermo,
Viale delle Scienze, 90128 Palermo
Italy
Publications
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Review Article
Aspects of Collagen Changes in Breast Cancer
Author(s): Claudio LuparelloClaudio Luparello
It is widely acknowledged that the Extracellular Matrix (ECM) of connective tissues plays active roles in numerous biological processes such as cell differentiation, life/death promotion and carcinogenesis. Breast cancer is commonly associated to drastic massive alterations of ECM architecture and composition, especially for what concerns its collagenous component. This mini-review is not aimed to give a comprehensive overview of this complex biological event, but to pick up selected early and recent studies on peculiar features of this field and recapitulate specific aspects related to collagen changes in the affected stroma, such as the re-appearance of OF/LB collagen the accumulation of type V collagen and the identification of tumour-associated collagen signatures at structural and gene expression levels. In addition, the effects of OF/LB and type V collagens on the phenotype of c.. View More»
DOI: 10.4172/2157-2518.S13-007