Guofeng Sun
IR Iran
Research Article
Dynamic Changes of Betatrophin and Its Potential Effect on β-cells in Spontaneously Developed or Streptozocin-induced Diabetes Monkeys
Author(s): Yongqiang Liu, Xiaoli Wang, Bingdi Wang, Guofeng Sun, Francine Gregoire, Keefe Chng, Jinhu Wang, Yixin (Jim) Wang and Yong-Fu XiaoYongqiang Liu, Xiaoli Wang, Bingdi Wang, Guofeng Sun, Francine Gregoire, Keefe Chng, Jinhu Wang, Yixin (Jim) Wang and Yong-Fu Xiao
Effects of betatrophin on β-cell proliferation and insulin secretion have been reported controversially in rodent studies. This study was to investigate the dynamic changes of betatrophin and its potential effect on β-cell function in non-human primates (NHPs). Blood betatrophin levels in naturally developed diabetes cynomolgus monkeys (n=65) significantly correlated with their body weights and blood glucose levels in the females (n=20) and with insulin and C-peptide levels in the males (n=45). Liver expression of betatrophin mRNA was markedly higher in spontaneously developed diabetes monkeys than in normoglycemic ones. Its liver expression correlated well with islet size and insulin content in normoglycemic cynomolgus monkeys and also well in spontaneously hyperglycemic (>200 mg/ dL) cynomolgus monkeys with high blood insulin level, but not well in those with very low b.. View More»
