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James R. Ewing is the Director of the Small Animal MRI/MRS laboratory, the PI of R01 CA135329-01 MRI Biomarkers of Response in Cerebral Tumors, and a Co-I on R01 CA129446-01 (PI Jiang, Feng) ADAM17 and Glioma-tumor Progression and Treatment. His long-term interests have been in developing noninvasive unbiased estimates of the parameters of cerebrovascular physiology, including cerebral blood flow (CBF), cerebral blood volume (CBV), the transvascular transfer constant, Ktrans, for an indicator, and such other related parameters as extracellular volume fraction, interstitial fluid pressure, and interstitial volume fraction. His expertise in MRI was developed with the aim of characterizing the sources of Magnetic Resonance Imaging (MRI) contrast in cerebral tissue, associating MRI contrast with specific cerebral pathologies, and utilizing sources of contrast, including contrast agent, to estimate the parameters of vascular physiology. He was trained as an experimental physicist, and my base expertise is in estimates of model parameters and the description of the errors, both systematic and random-like, of those parameters.
Parametric Estimates of Cerebrovascular Physiology, MRI Biomarkers of Response in Cerebral Tumors, MRI Measures of CA concentration,Specialized MRI sequences and post-processing