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Jan-Olov Strömberg
Jan-Olov Strömberg
Sweden
Publications
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Research Article
Genomic Instability or One-Gene Theory for Tumor Progression: A Breast Cancer Study
Author(s): Roland B Sennerstam and Jan-Olov StrömbergRoland B Sennerstam and Jan-Olov Strömberg
Objective: There is an ongoing debate in the literature as to whether human cancers originate from unique clones with single oncogene mutations or propagate from early established genomic instabilities due to intermediate metastable tetraploidization. The aim of this study was to investigate how far genomic instability, reflected in ploidy alterations, can explain tumor progression. Methods: In total 1,280 patients were involved in this study. We defined DNA-index (DI) intervals for diploid, tetraploid and aneuploid tumors and made simulations based on increasing age of patients, from 30 to 60 years old. We related this information to four enhancement steps of a parameter reflecting genomic instability generated from the tumor G1 peak coefficient of variation, S-phase fraction and number of cells exceeding G2 phase DNA region (stemline-scatter-index; SSI). The change in ploidy .. View More»
DOI: 10.4172/2157-2518.1000223