Research Article
Insulin Sensitization and Resistance Interrelationship in a Prediabetic Rat: A Quantitative Molecular Model
Author(s): Punna Ramulu, Nappan Veettil Giridharan, Paruchuri Udayasekhararao and Marasanapalle Kalle JanardanasarmaPunna Ramulu, Nappan Veettil Giridharan, Paruchuri Udayasekhararao and Marasanapalle Kalle Janardanasarma
Aims: To establish the insulin sensitization and resistance interrelationship through the quantitative modeling of number of insulin receptor molecules per molecule of insulin as response to plasma glucose levels.
Methods: Fenugreek seeds (FGS) powder and its soluble dietary fiber (SDF) were fed through diet to 50 day old prediabetic obese rats (WNIN/GR-Ob) for nine weeks. Fasting plasma glucose (FPG), fasting plasma insulin (FPI) levels and number of erythrocyte insulin receptors (NO-EIR) were determined. Data were analyzed for a) homeostatic model assessment for insulin resistance (HOMA-IRS), b) total number of insulin molecules in the plasma, c) total NO- EIR in one ml of blood and d) ratio of NO-EIR per molecule of FPI.
Results: The results showed a significant (p<0.05) reduction in FPG an.. View More»
