Journal of Stem Cell Research & Therapy

Paul BS Lai

Publications

• Research Article
  Topical Application of Adipose Tissue-Derived Mesenchymal Stem Cells Ameliorates Renal Ischemia-Reperfusion Injury in Rats
  Author(s): Ping-kuen Lam, Chi-fai NG, Wai-lun Tang, Anthony WI Lo, Cindy SW Tong, Don WC Chin, Kenneth HK Wong, Kin KY Lo, Richard KW Choy, Eddie SY Chan and Paul BS LaiPing-kuen Lam, Chi-fai NG, Wai-lun Tang, Anthony WI Lo, Cindy SW Tong, Don WC Chin, Kenneth HK Wong, Kin KY Lo, Richard KW Choy, Eddie SY Chan and Paul BS Lai
  
  Ischemia-Reperfusion Injury (IRI) was induced by clamping bilateral renal pedicles simultaneously for 60-min using bulldog clamps in Sprague-Dawley rats. They were then randomized into five groups: Group-I-3 × 106 MSCs were topically applied to the surface of each kidney with a layer of fibrin sealant, Group-II-only fibrin sealant was added, Group-III-only 3 × 106 MSCs were added, Group-IV-1 × 106 MSCs were injected directly into tail-vein and Group-V received no additional treatment (control). Serum creatinine in Group-I at Day-3 was significantly lower than the other groups. By Day-7, survival rates of animals with renal IRI were 81.3% in Group-I, 31.3% in Group-II, 37.6% in Group-III, 30.8% in Group-IV, and 25% in Group-V. At Day-3, histology of kidneys from Group-I showed less tubular necrosis and interstitial inflammation, when c.. View More»
  DOI: 10.4172/2157-7633.1000404

  Abstract PDF