alexa Genome-wide association

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Genome-wide association

Genome-wide association (GWA) studies have been extremely successful at identifying genomic regions associated with complex diseases and phenotypic traits.However, studies often do not go beyond reporting the most strongly associated genotyped single nucleotide polymorphism (SNP) and the best candidate gene within the region covered by the association signal. The researchers reported SNP is unlikely to be the causal variant and does not necessarily even identify the relevant gene. Thus the reported SNP is unlikely to characterize the relationship between genotype and phenotype, and hence may not add much to the understanding of disease aetiology.

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