alexa Molecular Genetic in Acute Myeloid Leukemias

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Molecular Genetic in Acute Myeloid Leukemias

Acute Myeloid Leukemias (AML) is a clonal hematopoietic disorder arising from the acquisition of genetic and epigenetic alterations, leading to a premature arrest of the normal differentiation of stem cells and to the accumulation of immature neoplastic cells in the blood and bone marrow. According to Bryd et al, almost 55% of newly diagnosed adult patients harbor non-random chromosomal abnormalities (e.g., deletions, translocations), which have long been recognized as the genetic events that cause and promote this disease.

 
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