alexa NAD(P)H:Quinone Oxidoreductase 1 Expression in Human Reproductive System and Mitomycin-C Cytotoxicity

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NAD(P)H:Quinone Oxidoreductase 1 Expression in Human Reproductive System and Mitomycin-C Cytotoxicity

NAD(P)H:quinone oxidoreductase 1 (NQO1; DT-diaphorase; DTD) is a cytosolic two-electron reductase, and compounds of the family of quinones such as mitomycin C are efficiently bio-activated by this enzyme. The observation that DT-diaphorase is over-expressed in many cancerous tissues compared to normal tissues has provided us with a selective target that can be exploited in the design of novel anticancer agents. Because information about the cell-specific expression of DT-diaphorase was so scarce, this study was initiated to map the distribution of this enzyme in human tissues.

Citation: Zappa F, Ward T, Pedrinis E, Butler J, McGown A (2013) NAD(P) H:Quinone Oxidoreductase 1 Expression in Human Reproductive System and Mitomycin-C Cytotoxicity: A New Chapter for Old Compounds? J Cytol Histol 5:209

 

 
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