The human polyomavirus, JC virus (JCV), is the causative agent of the demyelinating disease progressive multifocal leukoencephalopathy (PML), an increasingly common neurological complication in AIDS patients with approximately 8% of HIV-1 positive individuals developing this progressive disease. Greater than 80% of the population is infected with the human polyomavirus, JC virus (JCV) during childhood, though in the majority of infected individuals the virus establishes latency in the kidney and does not induce any overt signs of disease. In immunocompromised individuals such as AIDS patients, individuals on long term immunosuppressive therapies and individuals with lymphoproliferative disorders, however, reactivation of JCV results in the fatal demyelinating disease PML
Citation: Knight LC, Romano JE, Krynska B, Faro S, Mohamed FB, et al. (2010) Binding and Internalization of Iron Oxide Nanoparticles Targeted To Nuclear Oncoprotein. J Mol Biomark Diagn 1:102.