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Volume 8, Issue 5 (Suppl) J Addict Res Ther, an open access journal
ISSN: 2155-6105
6th World Congress on
August 29-31, 2017 | Prague, Czech Republic
Addiction Disorder & Addiction Therapy
Addiction Congress 2017
August 29-31, 2017
Transgenerational effect of adolescent male rat morphine exposure on pain perception and morphine
analgesia in the offspring
Narges Pachenari
Tarbiat Modares University, Iran
During thepast decades, use/misuseof opioidshasdramatically increasedamongadolescent population. It isfirmly confirmed
that different morphological and physiological changes occur in the brain during adolescence. Brain development and
maturation, during this critical period, could be affected by several factors, including stress, drug abuse, nutritional status,
etc. While studies on transgenerational effect of substances such as alcohol, nicotine and cocaine are focused on both paternal
and maternal drug exposure, most of the studies of morphine administration are restricted to maternal exposure. So in this
study we aimed to investigate transgenerational effect of male rats on morphine administration during adolescence against
pain perception and morphine analgesia in the offspring. Male rats received escalating doses of morphine for 10 days during
their adolescence. 20 days after last morphine injection, male rats were mated with intact female rats and then behavioral tests
conducted on the offspring. Pain perception was evaluated by formalin test, and morphine analgesia by formalin, tail flick and
paw withdrawal tests. Our results demonstrated that morphine and saline sired animals differ in interphase of formalin test.
Besides, morphine sired animals respondmore strongly to acute morphine injection in comparison to saline sired ones. Overall,
these findings indicate significant transgenerational effect of morphine exposure during adolescence on pain perception and
morphine analgesia in the offspring.
Biography
Narges Pachenari has earned her bachelor degree in animal biology at Tehran University and has done her master in medical physiology at Tarbiat Modares
University. Currently she is in the fourth year of PhD in the same university and doing her thesis in Dr. Semnanian’s lab. She is investigating the transgenerational
effect of morphine administration on the next generation.
Narges Pachenari, J Addict Res Ther 2017, 8:5 (Suppl)
DOI: 10.4172/2155-6105-C1-034