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conferenceseries.com
May 22-23, 2017 Las Vegas, USA
30th International Conference on
Dental Science & Advanced Dentistry
Volume 7, Issue 5 (Suppl) Dentistry
ISSN: 2161-1122, an open access journal Advanced Dentistry 2017
May 22-23, 2017
Preparation of mineralized nanocellulose hydrogel from some local agricultural residues and
assessment of their viability for use in osseous regeneration: An in vitro study
Engie Mohamed Moustafa Safwat1, Mohammad L. Hassan2, Dalia Y. Zaky3, Nehal F. Sharaf 4, Mervat Mohamed Fouad El Deftar5
1National Research Centre, Egypt
2 Cellulose and Paper Department & Advanced Materials and Nanotechnology Group, Centre of Excellence for Advanced Sciences, National Research Centre.
3 Restorative and Dental Materials Department, National Research Centre.
4 Restorative and Dental Materials Department, National Research Centre.
5 Assistant Professor of Pathology, Tissue Culture Unit, Pathology Department, National Cancer Institute, Cairo, Egypt
C ellulose is a naturally existing polymer, obtained from plants and microorganisms. It is a linear syndiotactic homopolymer
composed of D-anhydroglucopyranose units (AGU), which are linked together by β-(1-4)-glucosidic bonds. Cellulose-
based hydrogels have many advantages as they are biocompatible, transparent, low cost and non-toxic. Consequently,
cellulose-based hydrogels have wide applications in tissue engineering. Nanocellulose, specifically cellulose nanocrystals and
nanofibrillated cellulose have gained increasing interest as novel nanomaterial with unique properties, especially hydrogel-like
properties could be isolated from different lignocellulosic materials. In bone tissue engineering, addition of bioactive ceramics
into biodegradable polymers has several benefits. They increase the osteoconductivity of polymer. Bioactive ceramics can
also improve the attachment, differentiation and proliferation of osteoblasts and mesenchymal stem cells (MSCs). Among
the bioactive ceramic is biphasic calcium phosphate (BCP). Biphasic calcium phosphate is a mixture of two different calcium
phosphate phases: Hydroxyapatite (HA) and tricalcium phosphate (TCP) at different (HA/TCP) ratios. The aim of the present
study is to prepare and characterize injectable nanocellulose hydrogel from rice strawwastes and its mineralizationwith biphasic
calcium phosphate for dental bone tissue regeneration. The prepared hydrogel is in vitro assessed regarding cytotoxicity and
osteoblastic cells' differentiation. This project was supported financially by the Science and Technology Development Fund
(STDF), Egypt, Grant No. 5540
Biography
Engie M. Safwat has completed her PhD at the age of 35 years from Dental Biomaterial Departement, Faculty of Dentistry, Cairo University. she is a researcher
in the National Research Centre, a premier Egyptian research centre. she has published many papers in Egyptian journals and has a Patency no. 26383/ 2010
on 20/9/2010.from the “Academy of Scientific Research and Technology “Egyptian Patent Office, entitled (Preparation and evaluation of zinc phosphate cement
powder from Egyptian raw materials).
Engie Mohamed Moustafa Safwat et al., Dentistry 2017, 7:5 (Suppl)