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Global Summit on
October 26-27, 2018 | Boston, USA
Agriculture, Food Science and Technology
Advances in Crop Science and Technology | ISSN: 2329-8863 | Volume: 6
Investigation of anti-diabetic properties of haskap (
Lonicera caerulea
L.) berry polyphenols
Aruma Baduge Kithma Hansanee De Silva
Dalhousie University, Canada
H
askap (
Lonicera caerulea
L.), also known as blue honeysuckle, is a recently commercialized berry crop in Canada. Haskap
berries are rich in polyphenols, including anthocyanins, which are known for potential health-promoting effects. Cyanidin-3-
O-glucoside (C3G) is the most prominent anthocyanin of haskap berries. Recent literature reveals the efficacy of C3G in reducing the
risk of type 2 diabetes (T2D), which has become an increasingly common health issue around the world. The T2D is characterized
as a metabolic disorder of hyperglycemia and insulin resistance. It has been demonstrated that C3G has anti-diabetic effects through
various ways, including inhibition of dipeptidyl peptidase-4 (DPP-4), reduction of gluconeogenesis and inhibition of the formation of
advanced glycation end-products (AGEs), improvement in insulin sensitivity and inhibition of activities of carbohydrate-hydrolyzing
enzymes, including α-amylase and α-glucosidase. The proposed research investigates the influence of variety and harvests maturity of
haskap on C3G, other fruit quality characteristics and anti-diabetic activities of haskap berries using
in vitro
and
in vivo
studies. The
poster will address only the completed first objective of my Masters project as follows; Variety and harvesting maturity can influence
the polyphenol composition and biological properties of haskap berries. Haskap polyphenols, especially C3G exhibit anti-diabetic
properties through multiple mechanisms. The
in vitro
assays will be conducted to investigate the inhibitory properties of haskap
polyphenols on carbohydrate hydrolyzing enzymes and DPP-4. An established mice model will be used to determine serum glucose
concentration, AMPK activation and inhibition of gluconeogenesis enzymes upon the dietary intervention of haskap berries.
kithmadesilva@gmail.comAdv Crop Sci Tech 2018, Volume 6
DOI: 10.4172/2329-8863-C2-009