asia-pacific-mass-spectra-2016_posters-accepted-abstracts

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conferenceseries.com
Volume 7, Issue 7 (Suppl) J Chromatogr Sep Tech 2016
ISSN: 2157-7064 JCGST, an open access journal Mass Spectrometry 2016
October 10-11, 2016
October 10-11, 2016 Kuala Lumpur, Malaysia
3rd International Conference on
Mass Spectrometry
Jing Quan Lim et al., J Chromatogr Sep Tech 2016, 7:7 (Suppl)
Analysis of weight loss compounds adulterated in health supplements by LC-MS/MS
Jing Quan Lim, Wei Khee Wee and Yun Zeng
Health Sciences Authority, Singapore
In this study, an LC-MS/MS with scheduled MRM and EPI method was developed for simultaneous determination of 40 drug
substances with weight loss effect, including bisacodyl, phenolphthalein, sibutramine and its metabolites, etc. These drug substances
may be adulterated in health supplements to promote significant weight loss effects. The samples were analyzed using a Q-Trap 5500
LC-MS/MS using a CORTECS UPLC C18 column (100 mmx2.1 mmx1.6 µm). Scheduled MRMwas used as survey scan; MS2 spectra
acquired in the EPI mode were used to perform library searching to increase the confidence of detection. Good limits of detection
(LODs) were achieved using this methodology, where majority of the analytes were able to be detected at less than 10 ng/g levels.
Biography
Jing Quan Lim has completed his BSc from the Nanyang Technological University. He has experience in Pharmaceutical Testing, especially, in the areas of Western
Medicines and Complementary Health Products Analysis. He is currently the Team Leader at the Laboratory’s Western Medicines team and plays a vital role for
investigative samples.