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.com
Volume 8
Journal of Gastrointestinal & Digestive System
ISSN: 2161-069X
Bariatric Surgery 2018 & Gastro 2018
March 15-16, 2018
JOINT EVENT
12
th
Global Gastroenterologists Meeting
3
rd
International Conference on Metabolic and Bariatric Surgery
&
March 15-16, 2018 Barcelona, Spain
Epidemiological and clinical features of hospitalized patients with diarrhoea caused by Clostridium
difficile (C. difficile) infection in a teaching hospital in Croatia
Nikolina Bogdanić
1
and
Mirjana Balen Topić
1,2
1
University Hospital for Infectious Diseases Dr. Fran Mihaljević, Croatia
2
University of Zagreb, Croatia
Background:
Recent increase in disease severity, prevalence, and recurrence, as well as strong relationship with health services
has prompted research, surveillance, and development of preventive strategies for C. difficile infection (CDI). Since there
is scarce data available in Croatia, we performed this study to assess the epidemiological and clinical features of CDI in
hospitalized patients.
Materials & Methods:
This retrospective observational study included patients of all ages with laboratory confirmed CDI,
hospitalized at the 232-bedded University Hospital for Infectious Diseases Dr. Fran Mihaljević, Zagreb, Croatia during the
period from 2013 to 2016. The patients were divided to those with community-associated, with healthcare-associated, and
those with unknown CDI association. The disease severity was classified as mild, moderate, severe, and severe complicated.
The length of hospital stay (LOS) after CDI diagnosis, intensive care unit (ICU) treatment due to CDI and mortality rate were
observed as outcome indicators. Statistical analysis was performed to evaluate the differences between epidemiological groups
and to assess the trends through observed years.
Results:
Among 776 included patients 56.9% were females (p=0.0001), 75.6% were ≥65 years old, 75.8% had healthcare-
associated, 15.7% had community-associated CDI, and in 8.5% the association was unknown. Overall mortality rate was
10.2%, mean LOS was 13.9±14.0 days, and 2.4% of patients required ICU treatment due to CDI. In comparison to patients
with community-associated CDI, the proportion of patients with healthcare-associated CDI ranged from 79.5-85.8%, and
gradually increased (p=0.0395) through observed years. Patients with healthcare-associated CDI were older: median: 76vs70
years (p=0.0266), had higher disease severity (p<.0001), longer LOS: mean 14.83vs10.13 days (p<.0001) and higher mortality
rate (11.7vs.3.3%; p=0.0047), but the difference between the groups in the need for ICU treatment due to CDI (2.9vs1.6%) was
not significant (p=0.7560).
Conclusion:
Healthcare-associated CDIs present a growing problem in the hospital care of observed population. Increasing
incidence, high disease severity, high LOS and mortality rate suggest the need for improvement of efforts in preventing
healthcare-associated CDIs among Croatian population.
nikolinabogdanic@gmail.comJ Gastrointest Dig Syst 2018, Volume 8
DOI: 10.4172/2161-069X-C1-065