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Volume 8 Journal of Biotechnology and Biomaterials
ISSN: 2155-952X Biomaterials 2018
March 05-06, 2018
March 05-06, 2018 | Berlin, Germany
3rd Annual Conference and Expo on
Biomaterials
Development of fluorescentwater-solublehyperbranchedpolymers innanomaterials andbiomaterials
Tzong-Yuan Juang
China Medical University, Taiwan
In this study, we intend to used self-condensation of an AB2 monomer to prepare fluorescent hyperbranched poly (amido acids)
(HBPAAs) featuring wholly aliphatic backbones, multiple terminal CO2H units, and many internal tertiary amino and amido
moieties. Because tertiary amino groups are known to behave as fluorescent centers in dendritic structures, in this study we wish to
prepared AB2 monomer through an efficient synthetic scheme, involving blocking and deblocking processes, in high yield. Visible
blue photoluminescence self-emissions would be generated from the non-conjugated HBPAAs in aqueous solution; that is, bright
blue fluorescence behavior, with emission peaks at 395 nmand fluorescence QYs of up to 23%, appeared when the branching tertiary
amino moieties were embedded in a self-polymerized globular confinement. These amphiphilic HBPAAs also have potential for
use as tracing nanocarriers and molecular-level containers. Self-condensation of this AB2 building block to construct water-soluble
globular architectures with desired fluorescence properties appears to be a facile approach toward dendritic macromolecules with
labeling-delivery applications.
Recent publications
1. Lin L L, Chi M C, Lan E G, Lin M G, Juang T Y, et al. (2017) Facile immobilization of Bacillus licheniformis
γ-glutamyltranspeptidase onto graphene oxide nanosheets and its application to the biocatalytic synthesis of γ-l-glutamyl
peptides. International Journal of Biological Macromolecules pii: S0141-8130(17)32915-X.
2. Kan S C, Lee C C, Hsu Y C, Peng Y H, Chen C C, et al. (2017) Enhanced surfactin production via the addition of layered
double hydroxides. Journal of the Taiwan Institute of Chemical Engineers 80:10.
3. Juang T Y, Hsu Y C, Jiang B H and Chen C P (2016) Highly efficient inverted organic photovoltaics containing aliphatic
hyperbranched polymers as cathode modified layers. Macromolecules 49:7837.
4. Juang T Y, Kan S J, Chen Y Y, Tsai Y L, Lin M G, et al. (2014) Surface-functionalized hyperbranched poly(amido acid)
magnetic nanocarriers for covalent immobilization of a bacterial γ-glutamyltranspeptidase. Molecules 19:4997.
5. Su Y A, ChenWF, Juang T Y, Ting WH, Liu T Y, et al. (2014) Honeycomb-like polymeric films from dendritic polymers
presenting reactive pendent moieties. Polymer 55:1481.
Tzong-Yuan Juang, J Biotechnol Biomater 2018, Volume 8
DOI: 10.4172/2155-952X-C1-088