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Volume 10 Journal of Cancer Science & Therapy
ISSN: 1948-5956 Breast Cancer 2018
May 10-11, 2018
May 10-11, 2018 | Frankfurt, Germany
7th World Congress on Breast Cancer
Breast cancer: Correlation of ultrasonographic features with molecular subtype
Inês Vieites Branco1, Luciana Barbosa1, Lara Batista1, Anabela Ferrão2, Conceição Leal 2, Ana Teresa Aguiar2 and António Guimarães2
1Centro Hospitalar Vila Nova de Gaia, Espinho, Portugal
2Instituto Português de Oncologia do Porto, Portugal
Aims & Objectives: The purpose of this study is to correlate the ultrasonographic features of previously diagnosed malignant
breast cancers with their hormone receptor expression.
Methods & Materials: The malignant breast nodules diagnosed by ultrasonographic-guided core biopsy, at our regional
oncologic center, from July to December 2016 (n=172), had their ultrasound features retrospectively reviewed according to the
breast imaging- reporting and data system (BI-RADS) lexicon. For each case the molecular subtype was obtained, consisting
of positivity/negativity for hormone receptors (HR) and human epidermal growth factor receptor 2 (HER2), and correlated
to the ultrasonographic characteristics. The statistical analysis was conducted using the software Statistical Package for Social
Science (SPSS) v24, and a descriptive analysis using percentages was carried out, applying chi-square test for categorical data.
A significance level of p<0.05 was used to determine significance.
Results: HER2 and HR positive lesions showed more frequently an irregular morphology (78.6%, p=0.002) and non-parallel
orientation (78.6%, p=0.033). HER2 positive and HR negative lesions presented more commonly an irregular morphology
(94.4%, p=0.000), non-parallel orientation (88.9%, p=0.01) and lobulated margins (61.1%, p=0.016). HER2 negative and HR
positive lesions hadmore often an irregular morphology (85.4%, p=0.000), non-parallel orientation (88.8%, p=0.000), lobulated
margins (49.4%, p=0.000) and posterior attenuation (65.2%, p=0.004). HER2 and HR negative (triple negative) lesions showed
mainly an irregular morphology (94.1%, p=0.000), non-parallel orientation (88.2%, p=0.002), lobulated margins (58.8%,
p=0.028), and heterogeneous echotexture (82.4%, p=0.008).
Conclusion: Knowledge of distinctive ultrasonographic phenotypes according to molecular subtypes could be important for
earlier diagnosis and treatment, and ultimately improve outcomes.
Biography
Inês Vieites Branco is currently a third year Radiology Resident at Centro Hospitalar Vila Nova de Gaia-Espinho, Portugal, and has completed her Master’s degree
in Medicine from Instituto de Ciências Biomédicas de Abel Salazar- Porto, Portugal.
Inês Vieites Branco et al., J Cancer Sci Ther 2018, Volume 10
DOI: 10.4172/1948-5956-C2-126