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Volume 2, Issue 3(Suppl) Oncol Cancer Case Rep
ISSN: 2471-8556 an open access journal
Page 52
Notes:
Cancer Therapy & Biomarkers 2016
December 05-07, 2016
conferenceseries.com
CANCER THERAPY,
BIOMARKERS & CLINICAL RESEARCH
15th World Congress on
December 05-07, 2016 Philadelphia, USA
Protection against oral mucositis in patients undergoing radiotherapy of the head and neck with topical mu-
coadhesive gel containing Propolis
Vagner Rodrigues Santos, Vladimir R.A.S. Noronha, Henrique C. Meira, Ruan S. Silva, Mariana T. Rodrigues, Luis Guilherme V. Madeira, Mayara F.
Paiva and Barbara F. G. Queiroz.
Universidade Federal de Minas Gerais, Brazil
The objective of this phase II study was to determine the effectiveness of a mucoadhesive propolis gel in the prevention of
radiation-induced oral mucositis. Thirty-four patients who were selected to undergo radiation therapy for oral cancer
were included in this open-label trial. They were advised to use a mucoadhesive gel containing propolis 5,0% w/v three times
a day starting one day before the course of radiation therapy and concluding after 2 weeks of radiation therapy. A weekly
follow-up for evaluation of food intake, pain and grading of mucositis was performed. In order to confirm the absence of
Candida-related mucositis in patients who developed mucositis, it was performed exfoliative cytology of buccal mucosa,
palate and tongue and the material for Candifast() Candida species identification. At the end of the study was made the
compliance of patients, quality, appreciation and acceptance of product evaluation. Twenty patients did not develop mucositis,
two patients developed grade 1 mucositis and two patients developed grade 2 mucositis. None of the patients discontinued
food intake and no pain was observed during the study. Candidosis was not detected in any patient. Mucoadhesive propolis
gel could be considered as a potential topical medication for preventing radiation-induced oral mucositis.
Acnowledgements: FAPEMIG/CNPq/ CENEX-FOUFMG/PROEX-UFMG.
Biography
Vagner Rodrigues Santos is Graduate in Dentistry, Associate Professor at School of Dentistry of the Minas Gerais Federal University(SD/UFMG). He has PhD in
Oral Pathology (Faculty of Medicine/UFMG), Master in Microbiology(INRA–France), and Post-doctor in Natural Products at University of California Berkeley, USA.
He is coordinator of Dentistry Care Clinic to Irradiated in head and neck Patients. Participates in the post-graduate program , guides doctoral, master’s and
undergraduate research students. Search developing new drugs based on propolis and medicinal plants for prevention and treatment of oral lesions. He has 50
published papers with 387 citations by ResearchGate.
Vagner Rodrigues Santos et al., Oncol Cancer Case Rep 2016,2:3(Suppl)