cancer-therapy-and-biomarkers-2016_tracks-abstracts

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Volume 2, Issue 3(Suppl) Oncol Cancer Case Rep
ISSN: 2471-8556 an open access journal
Page 29
Notes:
Cancer Therapy & Biomarkers 2016
December 05-07, 2016
conferenceseries.com
CANCER THERAPY,
BIOMARKERS & CLINICAL RESEARCH
15th World Congress on
December 05-07, 2016 Philadelphia, USA
Pfetin as a risk factor of recurrence in Gastrointestinal Stromal Tumors
Shunsuke Sakuraba
Juntendo Shizuoka Hospital, Japan
We have proposed Pfetin as a new, strong prognostic biomarker in resected Gastrointestinal Stromal Tumors (GISTs).
Pfetin is a potassium channel protein. It is highly expressed in fetal cochlea and in the brain, consistent with the fact
that the origin of GIST is Cajal cells, and neuronal cells in the gut. Pfetin was discovered by using a proteomics approach and
its usefulness as a prognostic biomarker has been reported. We examine Pfetin expression immunohistochemically using par-
affin-embedded tissues, and when more than 20% of tumor cells are stained with the anti-Pfetin antibody, they are considered
to be Pfetin-positive. Pfetin expression and tumor metastasis were inversely related and GIST with Pfetin-negative status has
a poorer prognosis than Pfetin-positive GIST. We also have reported the fact that Pfetin is an independent predictor of recur-
rence/metastasis for completely resected primary, localized GIST. In our study, 13 cases were Pfetin-negative and 5/13 of these
cases recurred. Conversely, 32 cases were Pfetin-positive and 2/32 of these cases recurred. (p=0.002) Pfetin is a strong prognos-
tic biomarker and useful in selecting adjuvant therapy. We reviewed literatures and summarized Pfetin in GIST.
Biography
Shunsuke Sakuraba has completed his MD from Juntendo University. He works in the Department of Surgery at Juntendo Shizuoka Hospital and specializes in
Open Surgery, Laparoscopic Surgery and Endoscopic Surgery. He has published 2 papers about GIST and MALT lymphoma of GI tract.
Shunsuke Sakuraba, Oncol Cancer Case Rep 2016,2:3(Suppl)