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conferenceseries
.com
Volume 6
Journal of Cardiovascular Diseases & Diagnosis
Cardiology Care 2018
August 09-11, 2018
August 09-11, 2018 Abu Dhabi, UAE
Cardiology and Healthcare
28
th
International Conference on
Green tea extract improves diastolic dysfunction in pediatric cardiomyopathy patients: An observational study
Jie Tian
1
, Junjun Quan
1
and Xupei Huang
2
1
Chongqing Medical University, China
2
Atlantic International University, USA
H
ypertrophic Cardiomyopathy (HCM) and Restrictive Cardio-Myopathy (RCM) are the common genetic types of inheritable
heart disease and share a common pathophysiologic feature of diastolic dysfunction referring to an impaired cardiac
relaxation and a reduced ability in ventricular compliance during diastole. The efficient causative treatments of patients with
HCM or RCM are limited. Recent reports indicate the potential effect of Epigallocatechin-3-Gallate (EGCG), the most abundant
catechin in green tea, on reducing cardiac myofibril hypersensitivity to Ca
2+
to improve diastolic dysfunction. In this study, we
investigated changes of cardiac function, laboratory tests and clinical characteristic in cardiomyopathy patients with diastolic
dysfunction after consumption of Green Tea Extract (GTE). 13 cardiomyopathy patients with diastolic dysfunction underwent
clinical examinations, echocardiography, electrography and laboratory tests before and after daily consumption of GTE capsules
containing EGCG for at least 6 months. Next generation sequencing was conducted to find out candidate causative gene variants
in all patients. A significant decrease of isovolumetric relaxation time, an increase of left ventricle end diastolic volume and stroke
volume by echocardiography were observed after a at least 6-month period of GTE consumption. Left ventricular ejection fraction,
left ventricular wall thickness, biatrial dimension by echocardiography remained unchanged. No serious adverse effects were
reported in any patient. This observational study supports that EGCG, as GTE, have a potential effect on improving the impaired
relaxation in pediatric cardiomyopathy patients with diastolic dysfunction.
jietian@cqmu.edu.cnJ Cardiovasc Dis Diagn 2018, Volume 6
DOI: 10.4172/2329-9517-C1-003