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.com
Volume 8, Issue 5 (Suppl)
J Chromatogr Sep Tech, an open access journal
ISSN: 2157-7064
Chromatography 2017
August 07-09, 2017
August 07-09, 2017 | Rome, Italy
4
th
World Congress on
Chromatography
J Chromatogr Sep Tech 2017, 8:5(Suppl)
DOI: 10.4172/2157-7064-C1-032
Identify histone acetylation in acute lymphoblastic leukemia with liquid chromatography
Zhong J F, Zhang C, Stucky A, Chen X L, Press M F
and
Zhang X
University of Southern California, USA
H
igh-performance liquid chromatography (HPLC) has been used for the study of proteins and the characterization of their post-
translational modifications. Acute lymphoblastic leukemia (ALL) is generally considered as a genetic disease (disorder) with
an aggressive tumor entity of highly proliferative malignant lymphoid cells. However, in recent years, significant advances have been
made in the elucidation of the ALL-associated processes. Histone acetylation is involved in the permanent changes of gene expression
controlling ALL developmental outcomes. Identifying histone acetylation with HPLC could potentially provide a method for ALL
diagnosis and prognosis. Here, we used HPLC to profile histone acetylation from ALL bone marrow samples and correlated the result
to clinical outcomes. Initial results suggested that histone acetylation could be used for ALL prognosis and treatment evaluation.
jzhong@usc.edu