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Volume 2
Environment Pollution and Climate Change
ISSN: 2573-458X
Climate Change 2018 &
Global ENVITOX 2018
October 04-06, 2018
October 04-06, 2018
London, UK
16
th
Annual Meeting on
Environmental Toxicology and Biological Systems
&
5
th
World Conference on
Climate Change
JOINT EVENT
Bisphenol A affects the pulsing rate of
lumbriculus variegatus
via an estrogenic endocrine disrupting
mechanism
Yuyang Wang
1
and
Hong-Sheng Wang
2
1
Hefei No 8 Senior High School, China
2
University of Cincinnati, USA
B
isphenol A (BPA) is a widely used component of consumer plastics and a common environmental chemical. Previously,
we showed that BPA affected the physiology of the freshwater oligochaete
Lumbriculus variegatus.
In the present study, we
examined whether the impact of BPA on
L. variegatus
was mediated by an endocrine disrupting mechanism, using pulsing rate
of the dorsal blood vessel as the endpoint. Both long term and acute exposures to BPA increased the pulsing rate. The former
had a distinct inverted-U dose response relationship, while the latter had a monotonic one. The effects of BPA were mimicked
by the synthetic estrogen ethinylestradiol. The sensitivity of
L.variegatus
to estrogens was exquisite, with detectable effects at
pM range. Both the long term and acute effects of BPA were partially or fully blocked by various antagonists of mammalian
estrogen receptors, including ICI 182,780, MPP and G15. Our results suggest that the impacts of BPA on pulsing rate of
L. variegatus
are likely mediated by activation of an estrogen receptor. Our results also have implication for the endocrine
physiology of oligochaete, and for the evolution of estrogen receptors.
Biography
Yuyang Wang is a senior at Hefei No 8 Senior High School and is interested in zoology and biology. She performed the experiments reported here during the 2018 summer
recess in Dr. Hong-Sheng Wang’s laboratory in the Department of Pharmacology and Systems Physiology at the University of Cincinnati.
Yuyang Wang et al., Environ Pollut Climate Change 2018, Volume 2
DOI: 10.4172/2573-458X-C1-003