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conferenceseries
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Volume 2
Environment Pollution and Climate Change
ISSN: 2573-458X
Climate Change 2018 &
Global ENVITOX 2018
October 04-06, 2018
October 04-06, 2018
London, UK
16
th
Annual Meeting on
Environmental Toxicology and Biological Systems
&
5
th
World Conference on
Climate Change
JOINT EVENT
KIM-1 as a promising biomarker of kidney injury for human health risk assessment
Mariana del Carmen Cardenas Gonzalez
Brigham and Women’s Hospital—Harvard Medical School, USA
C
hronic kidney disease (CKD) is a serious public health problem with a high prevalence (~13%) worldwide. In addition to
the traditional risk factors of CKD, such as diabetes and hypertension, chronic exposure to environmental toxicants can
contribute to increasing the predisposition for development and/or progression of CKD. There are some hotspot areas with
high prevalence of CKD with unknown etiology (CKDu), where environmental risk factors have been suggested as important
triggers of this disease. Early detection is essential for estimating true prevalence and guiding preventive management.
Proximal tubule is the main target of environmental toxicants such as heavy metals and pesticides. One of the most sensitive
and specific biomarkers for kidney proximal tubular (PT) injury is KIM-1 (Kidney Injury Molecule-1). KIM-1 is a novel
non-invasive biomarker able to detect subclinical PT injury in a very sensitive and specific manner. We have investigated
KIM-1 performance on detecting PT injury in human populations living in different scenarios of environmental risks and
vulnerability. KIM-1 outperforms other kidney injury biomarkers having strong associations with environmental exposures,
distinguishing populations that may be more prone to developing CKD. KIM-1 may be a good candidate as a risk stratification
biomarker for environmental risk assessment.
mariana_cardenasgonalez@hms.harvard.eduEnviron Pollut Climate Change 2018, Volume 2
DOI: 10.4172/2573-458X-C1-003