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Clinical Gastroenterology 2016
October 03-05, 2016
Volume 6, Issue 6(Suppl) J Gastrointest Dig Syst
ISSN:2161-069X JGDS, an open access journal
conferenceseries .com
October 03-05, 2016 Toronto, Canada
8th International Conference on
Clinical Gastroenterology & Hepatology
Association of suppressor of cytokine signaling 3 polymorphisms with liver fibrosis progression in
Moroccan patients with chronic hepatitis C
Jadid Fatima Zahra1, 2, Chihab Hajar1, Tazi Sanaa1, EL Fihry Raouia1, Zaidane Imane1, Salih Alj Hanane2, Ezzikouri Sayeh1 and Benjelloun Soumaya1
1Institut Pasteur du Maroc, Morocco
2University of Hassan II Casablanca, Morocco
Context: Infection with hepatitis C virus (HCV) is one of the most important risk factors of hepatocellular carcinoma
(HCC). HCV is suspected to induce HCC primarily through chronic inflammation and promotion of cirrhosis. However, the
pathogenesis of insulin resistance (IR) in hepatitis C infection is a very intriguing problem. In fact, the HCV is now recognized
responsible for direct interference with the insulin signaling pathway. In addition, HCV-related IR has been shown to have a
remarkable clinical impact on the progression of hepatic fibrosis and development of HCC. In the liver, HCV core protein up-
regulates suppressor of cytokine signaling (SOCS-3) and (SOCS-1), which are known to inhibit insulin signaling by causing
ubiquitination of insulin receptor substrate (IRS-1) and (IRS-2) proteins. Genetic variations affecting this gene can induce
insulin resistance and decrease the response to interferon, both can accelerated the process of liver carcinogenesis.
Objective: This study aims to evaluate the association between SOSC-3 polymorphisms and progression liver fibrosis in
chronic hepatitis C infected patients.
Materials & Methods: In this study, 208 patients chronically infected with HCV (92 patients with moderate fibrosis and 116
patients with advanced fibrosis) were genotyped for 4874 A/G (rs4969170) and A+930-->G (rs4969168) variants using the real
time PCR.
Results: A significant difference in genotype distribution of rs4969168 and rs4969170 were detected between mild and
advanced fibrosis group. Although these results of SNP genotyping showed that the AA and GA genotypes are increased in
advanced fibrosis patients compared to mild fibrosis patients for both SNPs.
Conclusion: These findings indicated that recipient genetic factors play a role in HCV-related fibrosis progression. Molecular
studies of these pathways may elucidate the pathogenesis of fibrosis progression and provide risk prediction markers.
J Gastrointest Dig Syst 2016, 6:6(Suppl)