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conferenceseries
.com
Volume 7, Issue 5 (Suppl)
J Clin Trials, an open access journal
ISSN:2167-0870
Clinical Trials 2017
September 11-13, 2017
September 11-13, 2017 San Antonio, USA
4
th
International Conference on
Cl inical Tr ial s
A network-based pharmacology study of the potential hepatotoxicity of two common hepatoprotective
Chinese herbal medicines
Ming Hong
and
Yibin Feng
The University of Hong Kong, China
L
iver injury caused by hepatotoxic agents is a major health problem that challenges not only health care professionals but
also the drug regulatory agencies and the pharmaceutical industry in recent years. Traditional Chinese herbal medicines
such as Xiao chai hu tang (XCHT) and Heshouwu are widely used for chronic liver diseases and generally regarded as safe due
to their extensive clinical use. However, in recent years, there have been increased clinical case reports regarding the long-term
hepatotoxicity risks of these two hepatoprotective Chinese herbal medicines in patients with liver dysfunctions. Herein, based
on the network pharmacology framework, we analyzed the potential hepatotoxicity of XCHT and Heshouwu by predicting the
hepatotoxic ingredients and identify the molecular targets of hepatotoxicity in XCHT and Heshouwu. As a result, two drug-
target networks of hepatotoxicity of XCHT and Heshouwu were constructed and analyzed through network pharmacology
assays. This network pharmacology research on herbal hepatotoxicity may provide a forceful tool for exploring the potential
toxic ingredients and related intracellular mechanisms of Chinese herbal medicines. However, further experimental verification
of the potential hepatotoxicity compounds is needed to validate the accurate interactions between these herbal ingredients and
protein targets predicted by the
in-silico
method.
Biography
Ming Hong is a fourth year PhD student at the University of Hong Kong. His researches are mainly focused on Chinese medicines and liver diseases.
hong1986@connect.hku.hkMing Hong et al., J Clin Trials 2017, 7:5 (Suppl)
DOI: 10.4172/2167-0870-C1-019