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Dentistry | ISSN: 2161-1122 | Volume: 8
&
Dentistry & Dental Marketing
36
th
International Conference on
Oral Care & Oral Cancer
18
th
Annual Meeting on
October 24- 25, 2018 | Boston, USA
Basic aspects of bone reaction to implants
A
large variety of metal and ceramic devices are being introduced, on a daily basis, into bones. The appliances are implanted
in order to enhance healing, function and mobility. Bone repair adjacent to implants is a multi-factorial process wherein,
the foreign material is required, ideally, to produce a state of non-interference with normal osseous regeneration. The added
value of implant introduction comprises restoration of biomechanical properties. Ultimately, this process should involve an
improved formation of the mineralized matrix at the injured sites and an enhanced positive shift of bone remodeling balance.
Specifically, implant effect on bone healing involves a range of environmental, endocrine, mechanical and chemical variables
leading to changes in tissue, cell and gene expression. This is presented by the enhancement of guided action of osteoblasts and
chondroblast to produce osseous tissues that restore the skeletal load bearing capacity. Concomitantly, osteoclasts are involved
in the shaping of tissue healing. Recently, regulatory aspects of bone remodeling have been revealed. The findings disclosed
new modalities for induction, enhancement and guided repair in conditions such as intraosseous implants, nonunion fractures
and critical size defects. Various approaches to the treatment of these conditions are currently under basic, translational and
clinical research. These range from advanced methods for tissue engineering, gene and cell therapies involving identification
of active molecular target approach to the development of sophisticated biomaterials for implant surgery. In view of the
multidisciplinary nature of these efforts, the present talk addresses modern aspects of bone healing, with a special attempt to
enhance convergence of different experimental and clinical approaches designed for the study of implants and bone healing in
its diverse forms and under various conditions. The information and ideas provided should be of value for the understanding
of implant rejection in particular and at a broader view, to the experimental skeletal biologists and clinicians in the perception
of healing and regenerative processes.
Biography
Jona J Sela has been appointed full professor of Oral Pathology by The Hebrew University, Jerusalem, Israel at the age of 40 years. He served as Head, Division
of Oral Pathology and Chaired the Institute of Dental Reseach. Currently, director of the Laboratory of Biomineralization. He authored more than 250 publications
including books and has been serving as on editorial boards. His research interests comprise gene-expression of bone cells around dental and orthopedic implants.
His book "Principles of Bone Regeneration" was published by Springer Verlag US.
jjsela@cc.huji.ac.ilJona J Sela
The Hebrew University, Israel
Jona J Sela, Dentistry 2018, Volume 8
DOI: 10.4172/2161-1122-C7-046