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June 19-20, 2017 Philadelphia, USA



International Conference on

Clinical and Experimental Dermatology

Volume 8, Issue 4 (Suppl)

J Clin Exp Dermatol Res, an open access journal


Dermatology 2017

June 19-20, 2017

The divergent roles of growth differentiation factor-15 (GDF-15) in benign and malignant skin


Sevil Alan

Akdeniz University School of Medicine, Turkey


DF-15 (Growth Differentiation Factor-15) is a member of the transforming growth factor β (TGF-β) superfamily. GDF-15

is not only involved in cancer development, progression, angiogenesis and metastasis, but also controls stress responses,

bone formation, hematopoietic development, adipose tissue function and cardiovascular diseases. GDF-15 is regulated by

p53, has shown antitumorigenic and proapoptotic activities

in vivo


in vitro

. Also, GDF-15 is involved in skin biology and

histamine-induced melanogenesis; it is overexpressed in melanoma cells and is associated with depth of tumor invasion and

metastasis. GDF-15 level is increased in patients with systemic sclerosis and is related with the degree of skin sclerosis and

intensity of pulmonary fibrosis. In the future, GDF-15 may be a potential target for therapy in benign disorders with skin

fibrosis and malignant lesions of the skin.


Sevil Alan has received her PhD from Ege University, Turkey during the period of 1993-1999. She completed her Dermatology Residency at the Adana Numune

Education and Research Hospital in Adana, Turkey. Currently, she is working as a Dermatologist in Akdeniz University School of Medicine, Turkey. She is an

Editorial Board Member of journals like

SM Dermatology, Dermatology & Pigmentation Disorders

, and

International Journal of Clinical Dermatology



(IJCDR). She is serving as a Reviewer for journals like

JAMA Dermatology, International Research Journal of Public and Environmental Health, International

Medical Journal of Sifa University

. She has authored many research articles.

[email protected]

Sevil Alan, J Clin Exp Dermatol Res 2017, 8:4 (Suppl)

DOI: 10.4172/2155-9554-C1-059