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Volume 10
Journal of Cancer Science & Therapy
ISSN: 1948-5956
Euro Cancer 2018
July 23-25, 2018
July 23-25, 2018 | Rome, Italy
29
th
Euro-Global Summit on
Cancer Therapy & Radiation Oncology
Selective Internal Radiation therapy (SIRT) in the Angiography Suite
Grace Moscatelli
Western Sydney University, Australia
P
atients with isolated colorectal cancer (CRC) liver metastases require surgical resection as the treatment of choice when
feasible. Unfortunately most patients are not surgical candidates for this treatment option due to tumour size, location,
multifocality or insufficient hepatic reserve. One of the several nonsurgical treatment options available to patients who are
unable to receive resection who have liver-isolated CRC metastases is a procedure known as Selective Internal Radiation
Therapy (SIRT) also known as transarterial radioembolisation or radioembolisation. SIRT is a minimally invasive procedure
performed in the angiography suite (similar to theatres) by an Interventional Radiologist (proceduralist). There are two parts:
“work up” phase where the patient is assessed as an outpatient for suitability for the procedure then patient specific dose is
ordered followed by the SIR-Spheres Y-90 resin microspheres implantation phase both performed in the angiography suite.
The multidisciplinary team ensure that the patient is as comfortable and safe for the procedure ensuring an optimised journey
during this vulnerable period for the patient.The radiologist initially gains arterial access through the groin which may be
ultrasound guided and is followed by the introduction of guide wires and a thin catheter. Once the doctor identifies the hepatic
artery which is the primary blood supply feeding the liver tumours, millions of radioactive microspheres or SIR-Spheres are
implanted via the catheter directly to the liver tumours. The microspheres are about one third the diameter of a strand of hair in
size. Beta radiation is a common type of radiation used in nuclear medicine therapy and diagnostic procedures. This procedure
takes advantage of the fact that the portal vein is the primary blood supply for normal liver parenchyma and by selectively
irradiating tumours, the surrounding healthy tissue will be relatively unaffected. The patient would normally have a baseline
CT/ PET scan prior to the procedure followed by a progress scan between four weeks and three months post treatment.
Although this treatment is not a permanent cure, there is a greater possibility for patients who have primary or secondary
liver cancer to increase survival benefit in combination with quality of life and potentially undergo liver tumour resection or
liver transplant as the tumour size reduces especially when combined with standard chemotherapy. Although this is normally
a single treatment, some patients may be retreated with SIR-Spheres and procedural complications including pain and nausea
may be treated with analgesia and antiemetics. Reduced appetite, fever or tiredness may also be experienced by the patient for
several days post procedure though it is encouraged to maintain a healthy balanced diet.
Biography
Grace Moscatelli has completed her Bachelor of Nursing at University of Western Sydney and is currently studying Bachelor of Nursing with Professional Honours
Specialising in Anaesthetic and Recovery Nursing at University Of Tasmania. She is a Registered Nurse working in the Radiology, Nuclear Medicine and PET department
at a local Sydney hospital in Australia. She has presented at Medical Imaging Nurses Association National Conference in Melbourne in 2017.
gracem12@utas.edu.auGrace Moscatelli, J Cancer Sci Ther 2018, Volume 10
DOI: 10.4172/1948-5956-C8-144