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Volume 8, Issue 2 (Suppl) Chem Sci J 2017
ISSN: 2150-3494 CSJ, an open access journal Euro Chemistry 2017
May 11-13, 2017
May 11-13, 2017 Barcelona, Spain
4th European Chemistry Congress
Min Ji Park et al., Chem Sci J 2017, 8:2(Suppl)
Continuous glucose monitoring sensors modified with nitric oxide-releasing nanofiber for improving
biocompatibility: A freely-moving rat model
Min Ji Park1, Min Heo2, Yeong Rim Kim2, Gi Ja Lee 3 and Jae Ho Shin1,2*
1,2Kwangwoon University, Korea
3Kyung Hee University, Korea
The blood glucose levels of patients with diabetes mellitus should be tightly monitored. In general, diabetic patients have used
the strip-type glucose sensors. Because such strip-type sensors provide the instantaneous value, however, patients cannot
immediately respond to hyperglycemic or hypoglycemic events. On the other hand, in vivo glucose biosensors are able to determine
the glucose levels in real-time, allowing to effectively warn hyperglycemic or hypoglycemic conditions. Indeed, a continuous glucose
monitoring sensor provides maximal information about varying blood glucose levels throughout the day, and is able to facilitate
the making of optimal treatment decisions for diabetic patients. However, upon implantation of a sensor into a body, a cascade of
inflammatory response is initiated, ultimately making in vivo glucose measurement erratic. Therefore, the appropriate fusion of
biocompatible coating materials and glucose sensing devices has been one of the most critical issues. With discovery of nitric oxide
(NO) as a potent antithrombotic and anti-inflammatory agent, a variety of NO storage/release nanomaterials have been reported to
improve the biocompatibility of indwelled medical devices, including metal/metal oxide clusters, silica nanoparticles, dendrimers,
and polymeric nanofibers. Herein an implantable glucose microsensor modified with NO-releasing silica/polymer hybrid nanofibers
is demonstrated. By controlling NO release properties (e.g., total NO storage amount, half-life time of NO release, and maximum
flux), the sensor performance in vivo (using a freely-moving rat model equipped with a wireless signal transmitter/receiver device)
will is evaluated, in terms of sensor lifetime, accuracy, and stability.
Biography
Minji Park received her B.S. degree in Department of Chemistry at Kwangwoon University in 2015. Currently, she is studying for her M.S. degree in analytical
chemistry at the same University. Her research interest is mainly in the develpoment of glucose biosensor using electrochemical methods.