14 / 15
Page 54
conferenceseries
.com
Volume 7, Issue 5 (Suppl)
J Gastrointest Dig Syst, an open access journal
ISSN:2161-069X
Gastroenterology 2017
November 13-14, 2017
November 13-14, 2017 | Las Vegas, USA
13
th
International Conference on
Clinical Gastroenterology, Hepatology and Endoscopy
Study of n-terminal - pro c-type natriuretic peptide and its relation to risk of bleeding from esophageal
varices in hcv-related cirrhotic patients
Mohamed Asser
University of Alexandria, Egypt.
T
he current guidelines recommend that all cirrhotic patients should undergo screening endoscopy at diagnosis to identify patients
with risky varices who will benefit from primary prophylaxis. This leads to a heavy burden on endoscopy units and affects patient
compliance. Noninvasive identification of risky patients would limit performing endoscopy to those most likely to benefit. Upper
GIT endoscopy is the gold standard against which other tests are compared, but is not without its limitations. Some tests are clearly
preferable to patients but are not as accurate as upper GIT endoscopy in the diagnosis of esophageal varices. The aim of this work is to
study the relation of serum NT pro-CNP to severity of cirrhosis and the presence of esophageal varices and the risk of their bleeding.
The study was carried-out on 80 subjects divided into 4 groups: 20 cirrhotic patients with esophageal varices which have previously
bled, 20 cirrhotic patients with esophageal varices which have not yet bled, 20 cirrhotic patients without esophageal varices and 20
normal healthy control subjects. Serum NT pro-CNP level was significantly elevated in cirrhotic patients with esophageal varices
compared to cirrhotic patients without esophageal varices, but not significantly elevated in bleeders than in nonbleeders. Also spleen
and portal vein diameters, Child’s score, Fib-4 score, serum bilirubin and AST levels and prothrombin activity were significantly
elevated in the same group. Therefore, serum NT pro-CNP is a promising noninvasive marker for predicting severity of cirrhosis and
presence of esophageal varices and not the risk of variceal bleeding in HCV-related liver cirrhosis patients.
lotfy_1987@hotmail.comJ Gastrointest Dig Syst 2017, 7:5 (Suppl)
DOI: 10.4172/2161-069X-C1-056